|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Double luciferase reporter gene was used to verify the target regulatory relationship between miR-146 and NM23-H1 on a human breast cancer cell line. miR-146a was closely related to the proliferation and metastasis of breast cancer. miR-146a also promoted the growth of breast cancer in vivo via targeting NM23-H1.
|
31598678 |
2020 |
|
Breast Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Double luciferase reporter gene was used to verify the target regulatory relationship between miR-146 and NM23-H1 on a human breast cancer cell line. miR-146a was closely related to the proliferation and metastasis of breast cancer. miR-146a also promoted the growth of breast cancer in vivo via targeting NM23-H1.
|
31598678 |
2020 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Modulation of ILC2 function by miR-146a may depend on IL-33/interleukin 1 receptor-like 1 (IL1RL1 or ST2) signaling through inhibiting IRAK1 and TRAF6.miR-146a can inhibit IRAK1 and TRAF6, downstream molecules of ST2 signal pathway, thereby negatively regulate IL-33/ST2-activated ILC2 to inhibit asthma.
|
31435003 |
2020 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of miR-146a in patients in the cancer group was significantly higher than that in the normal group (p<0.05).
|
31646827 |
2020 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Double luciferase reporter gene was used to verify the target regulatory relationship between miR-146 and NM23-H1 on a human breast cancer cell line. miR-146a was closely related to the proliferation and metastasis of breast cancer. miR-146a also promoted the growth of breast cancer in vivo via targeting NM23-H1.
|
31598678 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beyond anti-inflammatory functions, miR146a is a known tumor suppressor commonly deleted or expressed at reduced levels in human myeloid leukemia.
|
31805184 |
2020 |
|
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previous research has certified that miR-146a attenuates osteoarthritis through the regulation of cartilage homeostasis.
|
31612476 |
2020 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report increased SERPINB2 expression in the skin of psoriasis patients, which was in a positive relationship with psoriasis severity and in a negative relationship with miR-146a/b in psoriatic lesions.
|
31630447 |
2020 |
|
Malignant neoplasm of prostate
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression level of miR-146a showed a trend of up-regulation in prostate cancer, and the expression level of miR-152 had a trend of down-regulation in prostate cancer, and the results of partial correlation analysis showed that the expression level of miR-146a and miR-152 was negatively correlated with each other in the serum of the patients with prostate cancer.
|
31646827 |
2020 |
|
Malignant neoplasm of prostate
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study was aimed to analyze the role of miR-146a, miR-196a2 and miR-125a gene polymorphisms in prostate cancer.
|
29594807 |
2020 |
|
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression level of miR-146a showed a trend of up-regulation in prostate cancer, and the expression level of miR-152 had a trend of down-regulation in prostate cancer, and the results of partial correlation analysis showed that the expression level of miR-146a and miR-152 was negatively correlated with each other in the serum of the patients with prostate cancer.
|
31646827 |
2020 |
|
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study was aimed to analyze the role of miR-146a, miR-196a2 and miR-125a gene polymorphisms in prostate cancer.
|
29594807 |
2020 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
MiR-146a-5p and HOTAIR positively regulated the migration and invasion of triple-negative breast cancer cells.
|
31672084 |
2020 |
|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
miR-146a promoted breast cancer proliferation and invasion by regulating NM23-H1.
|
31598678 |
2020 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of miR-146a in patients in the cancer group was significantly higher than that in the normal group (p<0.05).
|
31646827 |
2020 |
|
Triple Negative Breast Neoplasms
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
We showed that miR-146a-5p and long noncoding RNA HOTAIR were both upregulated in triple-negative breast cancer.
|
31672084 |
2020 |
|
Triple-Negative Breast Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
We showed that miR-146a-5p and long noncoding RNA HOTAIR were both upregulated in triple-negative breast cancer.
|
31672084 |
2020 |
|
B-Cell Lymphomas
|
0.050 |
Biomarker
|
group |
BEFREE |
Systemic administration of C-miR146a oligonucleotide alleviated human monocyte-dependent release of IL-1 and IL-6 in xenotransplanted B-cell lymphoma model without affecting CD19-specific CAR T-cell antitumor activity.
|
31805184 |
2020 |
|
Inflammatory dermatosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Psoriasis is a chronic inflammatory skin disease with numerous involved factors. miR-146a and miR-146b (miR-146a/b) are anti-inflammatory miRNAs that are increased in psoriatic skin.
|
31630447 |
2020 |
|
nervous system disorder
|
0.030 |
AlteredExpression
|
group |
BEFREE |
However, further investigations on the role of Tβ4 in regulating the expression of miR146a and TLR signaling pathway in the immune response adjustment in neurological disorders provides an insight into mechanisms of action and the possibility of Tβ4 therapeutic effect enhancement.
|
31612500 |
2020 |
|
Chronic small plaque psoriasis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here we aimed to study the relationship between miR-146a/b and SERPINB2 and to delineate the role of SERPINB2 in association of plaque psoriasis.
|
31630447 |
2020 |
|
Craniosynostosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, C-miR146a showed efficacy in dampening severe inflammation in clinically relevant models of chimeric antigen receptor (CAR) T-cell-induced cytokine release syndrome (CRS).
|
31805184 |
2020 |
|
Myeloproliferative disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results demonstrate potential of using myeloid cell-targeted miR146a mimics for treatment of inflammatory and myeloproliferative disorders.
|
31805184 |
2020 |
|
Schizophrenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This work was purposed to speculate the possible association of rs2910164hsa-miR-146a C>G gene single nucleotide polymorphism in the pathogenesis of schizophrenia and subsequently their relevance to neuro-inflammatory, vascular and oxidative stress pathways as acute ischemic stroke (AIS) risk factors in chronic schizophrenic patients.
|
31738890 |
2020 |
|
Secondary malignant neoplasm of bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression level of miR-146a in the patients with prostate cancer was closely related to clinical staging, the presence or absence of bone metastasis, tPSA and pathological staging (p<0.001) and the expression level of miR-152 in the patients with prostate cancer was closely related to clinical staging, the presence or absence of bone metastasis and pathological staging (p<0.001).
|
31646827 |
2020 |